Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function
نویسندگان
چکیده
منابع مشابه
Long noncoding RNA MEG3 suppressed endothelial cell proliferation and migration through regulating miR-21.
Long non-coding RNAs (lncRNAs) act critical roles in many biological processes, including cell proliferation, apoptosis, development, invasion and migration. LncRNA maternally expressed gene 3 (MEG3) is found to be downregulated in several tumors; however, its role in the atherosclerosis is still unknown. In the present study, we demonstrated that MEG3 expression level was downregulated in the ...
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BACKGROUND The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. METHODS Epigenetically controlled lncRNAs in human umbilical vein endothelial cells were searched by exon-array analysis after knockdown of the histone ...
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RATIONALE The human genome harbors a large number of sequences encoding for RNAs that are not translated but control cellular functions by distinct mechanisms. The expression and function of the longer transcripts namely the long noncoding RNAs in the vasculature are largely unknown. OBJECTIVE Here, we characterized the expression of long noncoding RNAs in human endothelial cells and elucidat...
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1Institute of Cardiovascular Regeneration, University Frankfurt, Frankfurt, Germany; 2Max-DelbrückCentrum für Molekulare Medizin (MDC), Berlin-Buch, Germany; 3GeorgSpeyer-Haus, Institute for Tumor Biology and Experimental Tumor Therapy, Frankfurt, Germany; 4Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany, and; 5German Center for Cardiovascular Research (DZHK), Partner sit...
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Osteoarthritis (OA) is becoming a major public health problem in China, especially considering the increase in average life expectancy of the population. Thus, enhanced understanding of the molecular changes associated with OA is urgently needed to develop more effective strategies for the diagnosis and treatment of this debilitating disease. LncRNAs play an important role in the processes of b...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2016
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2016.09.949